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RNA Synthesis and Modification IVT Product Portfolio

Nucleotide Solutions for RNA

NEB offers a variety of nucleotide solutions for RNA synthesis, including modified nucleotides, nucleotide solution sets, and mixes. These nucleotides are ultrapure (>95%)and supplied in sodium salt form. 

Complete substitution of canonical nucleotides with certain base-modified nucleotides can be used with our HiScribe Kits that are supplied with individual NTPs (NEB #E2040, E2070, E2080), whereas only partial substitutions are possible with HiScribe kits containing premixed NTPs (NEB #E2050, E2060, E2065).

 
Pseudouridine-modified mRNA

Pseudouridine modified mRNA 

Modified ribonucleotides can improve the utility of mRNA by increasing stability, reducing immunogenicity, enhancing translatability, or facilitating enrichment.


 

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Nucleotide Solutions for RNA

3´-Biotin-GTP

3´-Desthiobiotin-GTP

5-Methoxy-Uridine-5´-Triphosphate (5-Methoxy-UTP)

5-Methyl-Cytidine-5´-Triphosphate (5-Methyl-CTP)

DNase I (RNase-free)

DNase I-XT

E. coli Poly(A) Polymerase

E. coli RNA Polymerase, Core Enzyme

E. coli RNA Polymerase, Holoenzyme

HiScribe® SP6 RNA Synthesis Kit

HiScribe® T7 ARCA mRNA Kit

HiScribe® T7 ARCA mRNA Kit (with tailing)

HiScribe® T7 High Yield RNA Synthesis Kit

HiScribe® T7 mRNA Kit with CleanCap® Reagent AG

HiScribe® T7 Quick High Yield RNA Synthesis Kit

Hi-T7® RNA Polymerase

Hi-T7® RNA Polymerase (High Concentration)

m7G(5')ppp(5')G RNA Cap Structure Analog

N1-Methyl-Pseudouridine-5´-Triphosphate (N1-Methyl-Pseudo-UTP)

Poly(U) Polymerase

Pseudouridine-5´-Triphosphate (Pseudo-UTP)

Pyrophosphatase, Inorganic (E. coli)

Pyrophosphatase, Inorganic (yeast)

Ribonucleotide Solution Set

Ribonucleotide Solution Mix

RNase Inhibitor, Human Placenta

RNase Inhibitor, Murine

RNase Inhibitor, Murine (Glycerol-free)

SP6 RNA Polymerase

T3 RNA Polymerase

T7 RNA Polymerase

T7 RNA Polymerase (High Concentration)

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Protocols for Nucleotide Solutions for RNA
Legal Information

Products and content are covered by one or more patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc (NEB). The use of trademark symbols does not necessarily indicate that the name is trademarked in the country where it is being read; it indicates where the content was originally developed. All other trademarks are the property of their respective owners. The use of this product may require the buyer to obtain additional third-party intellectual property rights for certain applications. For more information, please email busdev@neb.com.

This product is intended for research purposes only. This product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.

 


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